For the humanists, whatever authority Scripture might possess derived from the original texts in their original languages, rather than from the Vulgate, which was increasingly recognized as unreliable and inaccurate. In that the catholic church continued to insist that the Vulgate was a doctrinally normative translation, a tension inevitably developed between humanist biblical scholarship and catholic theology...Through immediate access to the original text in the original language, the theologian could wrestle directly with the 'Word of God,' unhindered by 'filters' of glosses and commentaries that placed the views of previous interpreters between the exegete and the text. For the Reformers, 'sacred philology' provided the key by means of which the theologian could break free from the confines of medieval exegesis and return ad fontes to the title deeds of the Christian faith rather than their medieval expressions, to forge once more the authentic theology of the early church.

The medieval period based its scriptural exegesis upon the Vulgate translation of the Bible. There was no authorized version of this text, despite the clear need for a standardized text that had been carefully checked against its Hebrew and Greek originals. A number of versions of the text were in circulation, their divergences generally being overlooked. It was not until 1592 than an 'official' version of the text was produced by the church authorities, sensitive to the challenges to the authority of the Vulgate by Renaissance humanist scholars and Protestant theologians.