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In whatever disease sleep is laborious, it is a deadly symptom; but if sleep does good, it is not deadly.

Hippocrates , em The Aphorisms of Hippocrates
sleep science mortality disease immunology inflammation neuropsychoimmunology nrem sleep-medicine

With regard to sleep and waking, we must consider what they are: whether they are peculiar to soul or to body, or common to both; and if common, to what part of soul or body the appertain: further, from what cause it arises that they are atributes of animals, and whether all animals share in them both, or some partake of the one only, others of the other only, or some partake of neither and some of both.

Aristotle , em On Sleep and Sleeplessness
sleep sleeplessness wake neuroscience sleep-medicine comparative-biology hybrid-state sleep-science

Persons in whom a crisis takes place pass the night preceding the paroxysm uncomfortably, but the succeeding night generally more comfortably.

Hippocrates , em Aphorisms
stress release night insomnia crisis sleep-medicine diathesis sleep-disorder prodromal prognostic

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