In the abstract, it might be tempting to imagine that irreducible complexity simply requires multiple simultaneous mutations - that evolution might be far chancier than we thought, but still possible. Such an appeal to brute luck can never be refuted... Luck is metaphysical speculation; scientific explanations invoke causes.

Real arms races are run by highly intelligent, bespectacled engineers in glass offices thoughtfully designing shiny weapons on modern computers. But there's no thinking in the mud and cold of nature's trenches. At best, weapons thrown together amidst the explosions and confusion of smoky battlefields are tiny variations on old ones, held together by chewing gum. If they don't work, then something else is thrown at the enemy, including the kitchen sink - there's nothing "progressive" about that. At its usual worst, trench warfare is fought by attrition. If the enemy can be stopped or slowed by burning your own bridges and bombing your own radio towers and oil refineries, then away they go. Darwinian trench warfare does not lead to progress - it leads back to the Stone Age.

I declare that The Beatles are mutants. Prototypes of evolutionary agents sent by God, endowed with a mysterious power to create a new human species, a young race of laughing freemen.

We’ve now become the spectators of our own mutation. We may not die human anymore. But what makes us human?

You can't stop a soldier from being frightened but you can give him motivation to help him overcome that fear. I have no such motivation. I can't have. I'm a witcher: an artificially created mutant. I kill monsters for money. I defend children when their parents pay me to. If Nilfgaardian parents pay me, I'll defend Nilfgaardian children. And even if the world lies in ruin - which does not seem likely to me - I'll carry on killing monsters in the ruins of this world until some monster kills me. That is my fate, my reason, my life and my attitude to the world. And it is not what I chose. It was chosen for me.

In microbiology the roles of mutation and selection in evolution are coming to be better understood through the use of bacterial cultures of mutant strains.

It wasn't torpor that kept her - she was often restless to the point of irritability. She simply liked to feel that she was prevented from leaving, that she was needed.

Nature had been fucked with. And Mother was pissed.”... Mother Nature was funny that way. Complex. Unpredictable.And unforgiving as hell if you fucked around with her.