NASA astronauts have only managed to live continuously on the International Space Station (ISS) for a year and Biosphere 2 on Earth failed at two years of uninterrupted human habitation. Both cases required extracting the sickened people from the toxic environments. At this point it is ludicrous to talk about a permanent manned base on Mars.
Based on the medical evidence that clearly states that being above 10,000 feet is hazardous to the health of sea level adapted humans, it is clear that all of the manned facilities on top of the 13,796 feet Mauna Kea summit in Hawaii should be removed and the summit restored back to its native environment.
The scandal with the Thirty Meter Telescope (TMT) atop Mauna Kea is how it managed to obtain a construction permit to build a manned telescope in a known biologically toxic environment to workers. How many more people need to die, get injured or develop long term very high altitude sickness that will last a lifetime?