NASA astronauts have only managed to live continuously on the International Space Station (ISS) for a year and Biosphere 2 on Earth failed at two years of uninterrupted human habitation. Both cases required extracting the sickened people from the toxic environments. At this point it is ludicrous to talk about a permanent manned base on Mars.
Everyone I have spoken with about working with the Russians in space exploration believes that the United States has learned a great deal from Russia and that Russia has learned a great deal from the United States – and that the entire international space partnership is much better because of it.
We essentially had to build a docking mechanism between the two capsules. We didn't have to share a lot of data, and we did that at the height of the Cold War, which was pretty symbolic." –Bill Gerstenmaier