History, too, has a penchant for giving birth to itself over and over again, and those whom it appoints agents of change and progress do not always accept their destinies willingly.

He was now wealthy beyond his wildest dreams and wanted for nothing, so Columbus retired to Valladolid, which at one time was considered the capital of Castile and Leon, a historic region of northwestern Spain. On October 19, 1469, Queen Isabella and King Ferdinand had been married at the Palacio de los Vivero, in the city of Valladolid, giving it great significance for Columbus. It was only a year and a half after retiring, on May 20, 1506, that Christopher Columbus quietly died. Dr. Antonio Rodriguez Cuartero, a professor of Internal Medicine at the University of Granada, stated that the Admiral died of a heart attack caused by Reiter's Syndrome, also known as reactive arthritis. He was only 54 years of age; however, he had been suffering from arthritis for quite some time prior to his death.