The worst part of writing fiction is the fear of wasting your life behind a keyboard. The idea that, dying, you'll realize you only lived on paper. Your only adventures were make-believe, and while the world fought and kissed, you sat in some dark room masturbating and making money.
Our approach to existential risks cannot be one of trial-and-error. There is no opportunity to learn from errors. The reactive approach — see what happens, limit damages, and learn from experience — is unworkable. Rather, we must take a proactive approach. This requires foresight to anticipate new types of threats and a willingness to take decisive preventive action and to bear the costs (moral and economic) of such actions.
We cannot rely on trial-and-error approaches to deal with existential risks… We need to vastly increase our investment in developing specific defensive technologies… We are at the critical stage today for biotechnology, and we will reach the stage where we need to directly implement defensive technologies for nanotechnology during the late teen years of this century… A self-replicating pathogen, whether biological or nanotechnology based, could destroy our civilization in a matter of days or weeks.