NASA astronauts have only managed to live continuously on the International Space Station (ISS) for a year and Biosphere 2 on Earth failed at two years of uninterrupted human habitation. Both cases required extracting the sickened people from the toxic environments. At this point it is ludicrous to talk about a permanent manned base on Mars.

I am not a fan of sealed up sterile homes or Faraday cages and their use in human health, although I do understand that some people do feel relief in these environments.

Living in sterile man-made environments that are disconnected from nature should be expected to lead to sickness.

You can put the human mind and body into strange states through the use of alien environments.

There are four types of environments; the one that can help destroy you, the one that can help improve you, the one that can destroy the improved you and the one that can improve the destroyed you. Watch out and be vigilant!

In high altitude astronomical facilities we routinely discharged large amounts of nitrogen gas into closed spaces. We were never informed by the astronomy management team about the abnormally low oxygen environments that the use of liquid nitrogen creates, how long term exposure to it manifests itself in human health and the resulting abnormal mental behaviors.

Avoid working in windowless environments for good health.