THE MAXIMS OF MEDICINE Before you examine the body of a patient,Be patient to learn his story.For once you learn his story,You will also come to knowHis body.Before you diagnose any sickness,Make sure there is no sickness in the mind or heart.For the emotions in a man’s moon or sun,Can point to the sickness inAny one of his other parts.Before you treat a man with a condition,Know that not all cures can heal all people.For the chemistry that works on one patient,May not work for the next,Because even medicine has its ownConditions.Before asserting a prognosis on any patient,Always be objective and never subjective.For telling a man that he will win the treasure of life,But then later discovering that he will lose,Will harm him more than by telling himThat he may lose,But then he wins.THE MAXIMS OF MEDICINE by Suzy Kassem
Most women go through life looking for love, and looking for someone to treat them like a queen. For some women finding real love seems to be something that will never happen. I believe that finding love is not as hard as people make it seem. The reason that some women can't find real love is because they look for more than just real love. A lot of women know what they need in a relationship, and thats for a man to love that woman with all of his heart, and to treat her real good. Most women have guys in their life or guys that try to get with them that could really love them and treat them real good. Those are usually the guys that get forced into that friend zone or rejected upfront. See those guys could give them what they need, but not what they want. “Wants” can be anything from a woman wanting a man to have certain materialistic things, or she could want him to look a certain way, those are a few examples of the things that some of them want, but they vary depending on the female. What some females don't understand is that none of the things that they want has anything with love or how that person will treat you. You could find a man that looks perfect, has a house and car, he can be a college graduate with a good job, and you could still end up being with a person that doesn't truly love you, and will treat you like shit. What I am trying to say is that the person who could treat you good and really love you could already be in your life, but you could have been blinded by the things you want in a man so you overlooked the person that you were really looking for. And by the way there are men that do the same thing; I just wanted to be clear on that.
Змейк беседовал в углу с двумя металлами, недавно пробившимися из глубин Земли и не имеющими понятия о формах жизни на ее поверхности. Со всей вежливостью принимающей стороны он занимал гостей беседой, но трудно было сказать, насколько эта беседа занимала его самого. Собственно, Змейк собирался рассказать анекдот, однако необходимая для понимания анекдота преамбула даже при лаконичности Змейка потребовала не меньше минуты:— Люди состоят из соединений углерода и потребляют кислород. Смерть есть прекращение химических реакций одного типа, — Змейк поймал на себе взгляд Гвидиона, которого явно заинтересовал его учитель, дающий определение смерти, и спокойно закончил: — и начало совершенно иных химических реакций.
Thus, by science I mean, first of all, a worldview giving primacy to reason and observation and a methodology aimed at acquiring accurate knowledge of the natural and social world. This methodology is characterized, above all else, by the critical spirit: namely, the commitment to the incessant testing of assertions through observations and/or experiments — the more stringent the tests, the better — and to revising or discarding those theories that fail the test. One corollary of the critical spirit is fallibilism: namely, the understanding that all our empirical knowledge is tentative, incomplete and open to revision in the light of new evidence or cogent new arguments (though, of course, the most well-established aspects of scientific knowledge are unlikely to be discarded entirely).. . . I stress that my use of the term 'science' is not limited to the natural sciences, but includes investigations aimed at acquiring accurate knowledge of factual matters relating to any aspect of the world by using rational empirical methods analogous to those employed in the natural sciences. (Please note the limitation to questions of fact. I intentionally exclude from my purview questions of ethics, aesthetics, ultimate purpose, and so forth.) Thus, 'science' (as I use the term) is routinely practiced not only by physicists, chemists and biologists, but also by historians, detectives, plumbers and indeed all human beings in (some aspects of) our daily lives. (Of course, the fact that we all practice science from time to time does not mean that we all practice it equally well, or that we practice it equally well in all areas of our lives.)
Sometimes, you can be more than enough for someone, but they choose not to be in your life. Always remember that Satan works hard to keep people miserable by feeding their fears, so they stay in their comfort zone. The truth is some people value what is predictable, more than chemistry.
Will it be possible to solve these problems? It is certain that nobody has thus far observed the transformation of dead into living matter, and for this reason we cannot form a definite plan for the solution of this problem of transformation. But we see that plants and animals during their growth continually transform dead into living matter, and that the chemical processes in living matter do not differ in principle from those in dead matter. There is, therefore, no reason to predict that abiogenesis is impossible, and I believe that it can only help science if the younger investigators realize that experimental abiogenesis is the goal of biology.
And I often dream of chemistry at night, dreams that conflate the past and the present, the grid of the periodic table transformed to the grid of Manhattan. […] Sometimes, too, I dream of the indecipherable language of tin (a confused memory, perhaps, of its plaintive “cry”). But my favorite dream is of going to the opera (I am Hafnium), sharing a box at the Met with the other heavy transition metals—my old and valued friends—Tantalum, Rhenium, Osmium, Iridium, Platinum, Gold, and Tungsten.
All that happens in the human brain is but the result of electro-chemical reactions. Be it of love, hate, of pleasure, of suffering, of imagination, or all other states of mind, sentiment or sickness; the process depends in every case on the chemical reactions produced in the interior of the brain, and the resulting electrical impulses or messages, be they visual, auditory, based on memory, or an interpretation of new events based on elements that one has in the memory.
Together, we form a necessary paradox; not a senseless contradiction.
Dr. Morris soon recognized that the difference between successful and unsuccessful marriages can often be traced to how well couples are able to "bond" during the courtship period. By bonding he referred to the process by which a man and woman become cemented together emotionally. It describes the chemistry that permits two previous strangers to become intensely valuable to one another. It helps them weather the storms of life and remain committed in sickness and health, for richer or poorer, for better or worse, forsaking all others until they are parted in death. It is a phenomenal experience that almost defies description.
Lingering, bottled-up anger never reveals the 'true colors' of an individual. It, on the contrary, becomes all mixed up, rotten, confused, forms a highly combustible, chemical compound then explodes as something foreign, something very different than one's natural self.
A woman or man of value doesn’t love you because of what he or she wants you to be or do for them. He or she loves you because your combined souls understand one another, complements each other, and make sense above any other person in this world. You each share a part of their soul's mirror and see each other’s light reflected in it clearly. You can easily speak from the heart and feel safe doing so. Both of you have been traveling a parallel road your entire life. Without each other's presence, you feel like an old friend or family member was lost. It bothers you, not because you have given it too much meaning, but because God did. This is the type of person you don't have to fight for because you can't get rid of them and your heart doesn't want them to leave anyways.
Upon the whole, Chymistry is as yet but an opening science, closely connected with the useful and ornamental arts, and worthy the attention of the liberal mind. And it must always become more and more so: for though it is only of late, that it has been looked upon in that light, the great progress already made in Chymical knowledge, gives us a pleasant prospect of rich additions to it. The Science is now studied on solid and rational grounds. While our knowledge is imperfect, it is apt to run into error: but Experiment is the thread that will lead us out of the labyrinth.
A union of literary and scientific cultures – there was not the dissociation of sensibility that was so soon to come ... Davy himself was writing (and sometimes publishing) a good deal of poetry at the time; his notebooks mix details of chemical experiments, poems, and philosophical reflections all together; and these did not seem to exist in separate compartments in his mind.
The capital ... shall form a fund, the interest of which shall be distributed annually as prizes to those persons who shall have rendered humanity the best services during the past year. ... One-fifth to the person having made the most important discovery or invention in the science of physics, one-fifth to the person who has made the most eminent discovery or improvement in chemistry, one-fifth to the one having made the most important discovery with regard to physiology or medicine, one-fifth to the person who has produced the most distinguished idealistic work of literature, and one-fifth to the person who has worked the most or best for advancing the fraternization of all nations and for abolishing or diminishing the standing armies as well as for the forming or propagation of committees of peace.
We must trust to nothing but facts: These are presented to us by Nature, and cannot deceive. We ought, in every instance, to submit our reasoning to the test of experiment, and never to search for truth but by the natural road of experiment and observation.
Ostwald was a great protagonist and an inspiring teacher. He had the gift of saying the right thing in the right way. When we consider the development of chemistry as a whole, Ostwald's name like Abou ben Adhem's leads all the rest ... Ostwald was absolutely the right man in the right place. He was loved and followed by more people than any chemist of our time.
Any chemist reading this book can see, in some detail, how I have spent most of my mature life. They can become familiar with the quality of my mind and imagination. They can make judgements about my research abilities. They can tell how well I have documented my claims of experimental results. Any scientist can redo my experiments to see if they still work—and this has happened! I know of no other field in which contributions to world culture are so clearly on exhibit, so cumulative, and so subject to verification.
Japanese universities have a chair system that is a fixed hierarchy. This has its merits when trying to work as a laboratory on one theme. But if you want to do original work you must start young, and young people are limited by the chair system. Even if students cannot become assistant professors at an early age they should be encouraged to do original work....Industry is more likely to put its research effort into its daily business. It is very difficult for it to become involved in pure chemistry. There is a need to encourage long-range research, even if we don't know its goal and if its application is unknown.
I got into magic because I got into alchemy. Which I got into because I was into chemistry, which I was learning about because I wanted to get better with botany, which I had taken up studying in an effort to grow some killer weed
Let me tell you, you either have chemistry or you don't, and you better have it, or it's like kissing some relative. But chemistry, listen to me, you got to be careful. Chemistry is like those perfume ads, the ones that look so interesting and mysterious but you dont even know at first what they're even selling. Or those menues without the prices. Mystery and intrigue are gonna cost you. Great looking might mean something ve-ry expensive, and I don't mean money. What I'm saying is, chemistry is a place to start, not an end point.
We owe our liberation to chemistry," he went on. "For all perception is but a change in the concentration of hydrogen ions on the surface of the brain cells. Seeing me, you actually experience a disturbance in the sodium-potassium equilibrium across your neuron membranes. So all we have todo is send a few well-chosen molecules down into those cortical mitochondria, activate the right neurohumoral-synaptic transmission effector sites, and your fondest dreams come true. But you knowall this," he concluded, subdued.
We need science education to produce scientists, but we need it equally to create literacy in the public. Man has a fundamental urge to comprehend the world about him, and science gives today the only world picture which we can consider as valid. It gives an understanding of the inside of the atom and of the whole universe, or the peculiar properties of the chemical substances and of the manner in which genes duplicate in biology. An educated layman can, of course, not contribute to science, but can enjoy and participate in many scientific discoveries which as constantly made. Such participation was quite common in the 19th century, but has unhappily declined. Literacy in science will enrich a person's life.
Chemistry has the same quickening and suggestive influence upon the algebraist as a visit to the Royal Academy, or the old masters may be supposed to have on a Browning or a Tennyson. Indeed it seems to me that an exact homology exists between painting and poetry on the one hand and modem chemistry and modem algebra on the other. In poetry and algebra we have the pure idea elaborated and expressed through the vehicle of language, in painting and chemistry the idea enveloped in matter, depending in part on manual processes and the resources of art for its due manifestation.
One of my friends compared me to Bruce Banner, due to my work with radiation and human health. So I looked up Bruce Banner and this is what I found: Banner, a physicist, is sarcastic and seemingly very self-assured when he first appears in Incredible Hulk #1, but is also emotionally withdrawn in most fashions...Banner is considered one of the greatest scientific minds on Earth, possessing "a mind so brilliant it cannot be measured on any known intelligence test." He holds expertise in biology, chemistry, engineering, physiology, and nuclear physics.
On the stage Tristen bent over the piano, his fingers swift and sure, his blond hair gleaming under the spotlight. I glanced around at the audience, watching their faces, gratified that they were as captivated as I was by the dark, thunderous song that Tristen conjured.
When he put the old-fashioned mechanical toy on her palm, she stopped breathing. It was a tiny representation of an atom, complete with colored ball bearings standing in for neutrons, protons, and on the outside, arranged on arcs of fine wire, electrons. Turning the key on the side made the electrons move, what she’d thought were ball bearings actually finely crafted spheres of glass that sparked with color. A brilliant, thoughtful, wonderful gift for a physics major.“Why magnesium?” she asked, identifying the atomic number of the light metal. His hand on her jaw, his mouth on her own. “Because it’s beautifully explosive, just like my X.
I looked for it [heavy hydrogen, deuterium] because I thought it should exist. I didn't know it would have industrial applications or be the basic for the most powerful weapon ever known [the nuclear bomb] ... I thought maybe my discovery might have the practical value of, say, neon in neon s
Few scientists acquainted with the chemistry of biological systems at the molecular level can avoid being inspired. Evolution has produced chemical compounds exquisitely organized to accomplish the most complicated and delicate of tasks. Many organic chemists viewing crystal structures of enzyme systems or nucleic acids and knowing the marvels of specificity of the immune systems must dream of designing and synthesizing simpler organic compounds that imitate working features of these naturally occurring compounds.
The uniformity of the earth's life, more astonishing than its diversity, is accountable by the high probability that we derived, originally, from some single cell, fertilized in a bolt of lightning as the earth cooled. It is from the progeny of this parent cell that we take our looks; we still share genes around, and the resemblance of the enzymes of grasses to those of whales is a family resemblance.
Everything feels right with her. I can’t explain it. The world just stops. Everything freezes. It’s me. It’s her. It’s just us. Everything else, every molecule, including the oxygen we breathe, is only secondary to the chemistry we create. When we watch a movie it’s more than images strung together in the form of mindless entertainment. It’s an experience. An experience we share together from making the popcorn to watching the film to talking about it for days after. Chemistry. What more can I say? You either have it or you don’t.
It were indeed to be wish'd that our art had been less ingenious, in contriving means destructive to mankind; we mean those instruments of war, which were unknown to the ancients, and have made such havoc among the moderns. But as men have always been bent on seeking each other's destruction by continual wars; and as force, when brought against us, can only be repelled by force; the chief support of war, must, after money, be now sought in chemistry.
It was the first time! Just because there weren’t fireworks the first time doesn’t mean there will never be fireworks. We’re human; we’re adults; we teach each other; we communicate; fireworks don’t just go off, wham-bang; fireworks evolve!’Awestruck by the utter, asinine nonsense of this metaphor, everyone is still. Into the stillness, the ample woman drops the word ‘Wrong.’ Then she says it again. ‘Wrong…I’m talking about science…Pheromones.’ The woman turns to Cornelia. ‘The chemicals in his body call out. The chemicals in your body answer. It either happens or it doesn’t.’On top of being dumb, Cornelia is dumbfounded.
Dissection ... teaches us that the body of man is made up of certain kinds of material, so differing from each other in optical and other physical characters and so built up together as to give the body certain structural features. Chemical examination further teaches us that these kinds of material are composed of various chemical substances, a large number of which have this characteristic that they possess a considerable amount of potential energy capable of being set free, rendered actual, by oxidation or some other chemical change. Thus the body as a whole may, from a chemical point of view, be considered as a mass of various chemical substances, representing altogether a considerable capital of potential energy.
I had found by experience that putting things down on paper helped to clear the mind in precisely the same way, as Mrs. Mullet had taught me, that an eggshell clarifies the consommé or the coffee, which, of course, is a simple matter of chemistry. The albumin contained in the eggshell has the property of collecting and binding the rubbish that floats in the dark liquid, which can then be removed and discarded in a single reeking clot: a perfect description of the writing process.
Briefly, in the act of composition, as an instrument there intervenes and is most potent, fire, flaming, fervid, hot; but in the very substance of the compound there intervenes, as an ingredient, as it is commonly called, as a material principle and as a constituent of the whole compound the material and principle of fire, not fire itself. This I was the first to call phlogiston.
In the vestibule of the Manchester Town Hall are placed two life-sized marble statues facing each other. One of these is that of John Dalton ... the other that of James Prescott Joule. ... Thus the honour is done to Manchester's two greatest sons—to Dalton, the founder of modern Chemistry and of the atomic theory, and the laws of chemical-combining proportions; to Joule, the founder of modern physics and the discoverer of the Law of Conservation of Energy.One gave to the world the final proof ... that in every kind of chemical change no loss of matter occurs; the other proved that in all the varied modes of physical change, no loss of energy takes place.
I would like to start by emphasizing the importance of surfaces. It is at a surface where many of our most interesting and useful phenomena occur. We live for example on the surface of a planet. It is at a surface where the catalysis of chemical reactions occur. It is essentially at a surface of a plant that sunlight is converted to a sugar. In electronics, most if not all active circuit elements involve non-equilibrium phenomena occurring at surfaces. Much of biology is concerned with reactions at a surface.
The chemists are a strange class of mortals, impelled by an almost insane impulse to seek their pleasures amid smoke and vapour, soot and flame, poisons and poverty; yet among all these evils I seem to live so sweetly that may I die if I were to change places with the Persian king.
you're Shane, right?'He inched away from her and managed a quick nod as he twisted the rag he held in his fingers. 'Heidi sad you were willing to teach me how to ride.' Her expression shifted from entertained to confused, as if she was wondering why no one had mentioned he was a can or two shy of a six-pack. 'A horse,' he clarified, then wanted to kick himself. What else but a horse? Did he think she was here to learn to ride his mother's elephant? One corner of Annabelle's perfect, full mouth twitched. 'A horse would be good. You seem to have several.'He wanted to remind himself that he was usually fine around women. Smooth even. He was intelligent, funny and could, on occasion, be charming. Just not now, with his blood pumping and his brain doing nothing more than shouting "it's her, it's her" over and over again. Chemistry, he thought grimly. It could turn the smartest man into a drooling idiot. Here he was, proving the theory true.
[The] structural theory is of extreme simplicity. It assumes that the molecule is held together by links between one atom and the next: that every kind of atom can form a definite small number of such links: that these can be single, double or triple: that the groups may take up any position possible by rotation round the line of a single but not round that of a double link: finally that with all the elements of the first short period [of the periodic table], and with many others as well, the angles between the valencies are approximately those formed by joining the centre of a regular tetrahedron to its angular points. No assumption whatever is made as to the mechanism of the linkage. Through the whole development of organic chemistry this theory has always proved capable of providing a different structure for every different compound that can be isolated. Among the hundreds of thousands of known substances, there are never more isomeric forms than the theory permits.
That the nobility of Man, acquired in a hundred centuries of trial and error, lay in making himself the conquerer of matter, and that I had enrolled in chemistry because I wanted to maintain faithful to that nobility. That conquering matter is to understand it, and understanding matter is necessary to understanding the universe and ourselves: and that therefore Mendeleev’s Periodic Table, which just during those weeks we were laboriously learning to unravel, was poetry, loftier and more solemn than all the poetry we had swallowed doen in liceo; and come to think of it, it even rhymed! …[T]he chemistry and physics on which we fed, besides being in themselves nourishments vital in themselves, were the antidotes to Fascism … because they were clear and distinct and verifiable at every step, and not a tissue of lies and emptiness like the radio and newspapers.
Science began with a gadget and a trick. The gadget was the wheel; the trick was fire. We have come a long way from the two-wheel cart to the round-the-world transport plane, or from the sparking flint to man-made nuclear fission. Yet I wonder whether the inhabitants of Hiroshima were more aware of the evolution of science than ancient man facing an on-storming battle chariot.It isn't physics that will make this a better life, nor chemistry, nor sociology. Physics may be used to atom-bomb a nation and chemistry may be used to poison a city and sociology has been used to drive people and classes against classes. Science is only an instrument, no more than a stick or fire or water that can be used to lean on or light or refresh, and also can be used to flail or burn or drown. Knowledge without morals is a beast on the loose.
The dogma of the impossibility of determining the atomic constitution of substances, which until recently was advocated with such fervor by the most able chemists, is beginning to be abandoned and forgotten; and one can predict that the day is not far in the future when a sufficient collection of facts will permit determination of the internal architecture of molecules. A series of experiments directed toward such a goal is the object of this paper.
Planck...and Bohr...have invented systems containing electrons of which the motion produces no effect upon external charges...[N]ot only [is this] inconsistent with the accepted laws of electromagnetism, but I may add, is logically objectionable, for that state of motion which produces no physical effect whatsoever may better be called a state of rest.
In the last four days I have got the (results) given by Tantalum, Chromium, Manganese, Iron , Nickel, Cobalt and Copper ... The chief result is that ... the result for any metal (is) quite easy to guess from the results for the others. This shews that the insides of all the atoms are very much alike, and from these results it will be possible to find out something of what the insides are made up of.
I studied calculus for the first time, which to me was an amazingly empowering experience which I could really see how you could understand all sorts of things, and I decided that chemistry and biology just had too much memory for me to be interested. Physics was very easy.
It has been demonstrated that a species of penicillium produces in culture a very powerful antibacterial substance which affects different bacteria in different degrees. Generally speaking it may be said that the least sensitive bacteria are the Gram-negative bacilli, and the most susceptible are the pyogenic cocci ... In addition to its possible use in the treatment of bacterial infections penicillin is certainly useful... for its power of inhibiting unwanted microbes in bacterial cultures so that penicillin insensitive bacteria can readily be isolated.
During this time (at high school) I discovered the Public Library... It was here that I found a source of knowledge and the means to acquire it by reading, a habit of learning which I still follow to this day. I also became interested in chemistry and gradually accumulated enough test tubes and other glassware to do chemical experiments, using small quantities of chemicals purchased from a pharmacy supply house. I soon graduated to biochemistry and tried to discover what gave flowers their distinctive colours. I made the (to me) astounding discovery that the pigments I extracted changed their colours when I changed the pH of the solution.
Will fluorine ever have practical applications?It is very difficult to answer this question. I may, however, say in all sincerity that I gave this subject little thought when I undertook my researches, and I believe that all the chemists whose attempts preceded mine gave it no more consideration.A scientific research is a search after truth, and it is only after discovery that the question of applicability can be usefully considered.
The discovery of an interaction among the four hemes made it obvious that they must be touching, but in science what is obvious is not necessarily true. When the structure of hemoglobin was finally solved, the hemes were found to lie in isolated pockets on the surface of the subunits. Without contact between them how could one of them sense whether the others had combined with oxygen? And how could as heterogeneous a collection of chemical agents as protons, chloride ions, carbon dioxide, and diphosphoglycerate influence the oxygen equilibrium curve in a similar way? It did not seem plausible that any of them could bind directly to the hemes or that all of them could bind at any other common site, although there again it turned out we were wrong. To add to the mystery, none of these agents affected the oxygen equilibrium of myoglobin or of isolated subunits of hemoglobin. We now know that all the cooperative effects disappear if the hemoglobin molecule is merely split in half, but this vital clue was missed. Like Agatha Christie, Nature kept it to the last to make the story more exciting. There are two ways out of an impasse in science: to experiment or to think. By temperament, perhaps, I experimented, whereas Jacques Monod thought.
At my urgent request the Curie laboratory, in which radium was discovered a short time ago, was shown to me. The Curies themselves were away travelling. It was a cross between a stable and a potato-cellar, and, if I had not seen the worktable with the chemical apparatus, I would have thought it a practical joke.(Wilhelm Ostwald on seeing the Curie's laboratory facilities.)
A demonstrative and convincing proof that an acid does consist of pointed parts is, that not only all acid salts do Crystallize into edges, but all Dissolutions of different things, caused by acid liquors, do assume this figure in their Crystallization; these Crystalls consist of points differing both in length and bigness from one another, and this diversity must be attributed to the keener or blunter edges of the different sorts of acids.
There was something ghost-like and insubstantial about gases to these early chemists. They called liquids that turned into gases easily, "spirits." Methyl alcohol, they called "wood spirit"; ethyl alcohol, "wine spirit." Even today, alcoholic beverages are frequently referred to as "spirits." (Modern Arabs, from whose language the word "alcohol" was taken, call ethyl alcohol "spirit" from the English. This is a queer exchange.)
I took a glass retort, capable of containing eight ounces of water, and distilled fuming spirit of nitre according to the usual method. In the beginning the acid passed over red, then it became colourless, and lastly again all red: no sooner did this happen, then I took away the receiver; and tied to the mouth of the retort a bladder emptied of air, which I had moistened in its inside with milk of lime lac calcis, (i.e. lime-water, containing more quicklime than water can dissolve) to prevent its being corroded by the acid. Then I continued the distillation, and the bladder gradually expanded. Here-upon I left every thing to cool, tied up the bladder, and took it off from the mouth of the retort.— I filled a ten-ounce glass with this air and put a small burning candle into it; when immediately the candle burnt with a large flame, of so vivid a light that it dazzled the eyes. I mixed one part of this air with three parts of air, wherein fire would not burn; and this mixture afforded air, in every respect familiar to the common sort. Since this air is absolutely necessary for the generation of fire, and makes about one-third of our common air, I shall henceforth, for shortness sake call it empyreal air, [literally fire-air] the air which is unserviceable for the fiery phenomenon, and which makes abut two-thirds of common air, I shall for the future call foul air [literally corrupted air].
As the physicist Paul Davies puts it, 'If everything needs everything else, how did the communities of molecules ever arise in the first place?' It is rather as if all the ingredients in your kitchen somehow got together and baked themselves into a cake - but a cake that could moreover divide when necessary to produce more cakes. It is little wonder that we call it the miracle of life. It is also little wonder that we have barely begun to understand it.
Chloroplasts bear chlorophyll; they give the green world its color, and they carry out the business of photosynthesis. Around the inside perimeter of each gigantic cell trailed a continuous loop of these bright green dots. They spun . . . they pulsed, pressed, and thronged . . . they shone, they swarmed in ever-shifting files around and around the edge of the cell; they wandered, they charged, they milled, raced . . . they flowed and trooped greenly . . . All the green in the planted world consists of these whole, rounded chloroplasts . . . If you analyze a molecule of chlorophyll itself, what you get is one hundred thirty-six atoms of hydrogen, carbon, oxygen, and nitrogen arranged in an exact and complex relationship around a central ring. At the ring’s center is a single atom of magnesium. Now: If you remove the atom of magnesium and in its place put an atom of iron, you get a molecule of hemoglobin. The iron atom combines with all the other atoms to make red blood, the streaming red dots in the goldfish’s tail.
In describing a protein it is now common to distinguish the primary, secondary and tertiary structures. The primary structure is simply the order, or sequence, of the amino-acid residues along the polypeptide chains. This was first determined by [Frederick] Sanger using chemical techniques for the protein insulin, and has since been elucidated for a number of peptides and, in part, for one or two other small proteins. The secondary structure is the type of folding, coiling or puckering adopted by the polypeptide chain: the a-helix structure and the pleated sheet are examples. Secondary structure has been assigned in broad outline to a number of librous proteins such as silk, keratin and collagen; but we are ignorant of the nature of the secondary structure of any globular protein. True, there is suggestive evidence, though as yet no proof, that a-helices occur in globular proteins, to an extent which is difficult to gauge quantitatively in any particular case. The tertiary structure is the way in which the folded or coiled polypeptide chains are disposed to form the protein molecule as a three-dimensional object, in space. The chemical and physical properties of a protein cannot be fully interpreted until all three levels of structure are understood, for these properties depend on the spatial relationships between the amino-acids, and these in turn depend on the tertiary and secondary structures as much as on the primary. Only X-ray diffraction methods seem capable, even in principle, of unravelling the tertiary and secondary structures.[Co-author with G. Bodo, H. M. Dintzis, R. G. Parrish, H. Wyckoff, and D. C. Phillips]
A DNA sequence for the genome of bacteriophage ΦX174 of approximately 5,375 nucleotides has been determined using the rapid and simple 'plus and minus' method. The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs. Two pairs of genes are coded by the same region of DNA using different reading frames.
For it is not cell nuclei, not even individual chromosomes, but certain parts of certain chromosomes from certain cells that must be isolated and collected in enormous quantities for analysis; that would be the precondition for placing the chemist in such a position as would allow him to analyse [the hereditary material] more minutely than [can] the morphologists ... For the morphology of the nucleus has reference at the very least to the gearing of the clock, but at best the chemistry of the nucleus refers only to the metal from which the gears are formed.
My laboratory is interested in the related challenges of understanding the origin of life on the early earth, and constructing synthetic cellular life in the laboratory. Focusing on artificial life frees us to explore novel chemical systems, but what we learn from these systems helps us to understand possible pathways leading to the origin of life. Our basic design for a synthetic cell involves the encapsulation of a spontaneously replicating nucleic acid, which acts as the genetic material, within a spontaneously replicating membrane vesicle, which provides spatial localization. We are using chemical synthesis to make nucleic acids with modified nucleobases and sugar-phosphate backbones.
I wasn’t aware of just how close he’d moved to me until now. So many details came into focus. The shape of his lips, the line of his neck. “I’m not dangerous,” I breathed.He brought his face toward mine. “You are to me.”And somehow, against all reason, we were kissing. I closed my eyes, and the world around me faded. The noise, the smoke . . . it was gone. All that mattered was the taste of his mouth, a mix of cloves and mints. There was a fierceness in his kiss, a desperation . . . and I answered, just as hungry for him. I didn’t stop him when he pulled me closer, so that I almost sat on his lap. I’d never been wrapped around someone’s body like that, and I was shocked at how eagerly mine responded. His arm went around my waist, pulling me onto him further, and his other hand slid up the back of my neck, getting entangled in my hair. He took his lips away from my mouth, gently trailing kisses down to my neck. I tipped my head back, gasping when the intensity returned to his mouth. There was an animalistic quality that sent shock waves through the rest of my body.
For the first time I saw a medley of haphazard facts fall into line and order. All the jumbles and recipes and hotchpotch of the inorganic chemistry of my boyhood seemed to fit into the scheme before my eyes—as though one were standing beside a jungle and it suddenly transformed itself into a Dutch garden.[Upon hearing the Periodic Table explained in a first-tern university lecture.]
[Henry Cavendish] fixed the weight of the earth; he established the proportions of the constituents of the air; he occupied himself with the quantitative study of the laws of heat; and lastly, he demonstrated the nature of water and determined its volumetric composition. Earth, air, fire, and water—each and all came within the range of his observations.
The chemists who uphold dualism are far from being agreed among themselves; nevertheless, all of them in maintaining their opinion, rely upon the phenomena of chemical reactions. For a long time the uncertainty of this method has been pointed out: it has been shown repeatedly, that the atoms put into movement during a reaction take at that time a new arrangement, and that it is impossible to deduce the old arrangement from the new one. It is as if, in the middle of a game of chess, after the disarrangement of all the pieces, one of the players should wish, from the inspection of the new place occupied by each piece, to determine that which it originally occupied.
Almost all the world is natural chemicals, so it really makes you re-think everything. A cup of coffee is filled with chemicals. They've identified a thousand chemicals in a cup of coffee. But we only found 22 that have been tested in animal cancer tests out of this thousand. And of those, 17 are carcinogens. There are ten milligrams of known carcinogens in a cup of coffee and thats more carcinogens than you're likely to get from pesticide residues for a year!