NASA astronauts have only managed to live continuously on the International Space Station (ISS) for a year and Biosphere 2 on Earth failed at two years of uninterrupted human habitation. Both cases required extracting the sickened people from the toxic environments. At this point it is ludicrous to talk about a permanent manned base on Mars.
The terrors of the future will not come from the drab repressions of an encroaching bureaucracy, but from the neon lights of a thousand supermarkets, the sounds of a million automobile accidents and from the public cremation of the dead astronauts as they return to earth.
My optimism and confidence come not from feeling I'm luckier than other mortals, and they sure don't come from visualizing victory. They're the result of a lifetime spent visualizing defeat and figuring out how to prevent it. Like most astronauts, I'm pretty sure that I can deal with what life throws at me because I've thought about what to do if things go wrong, as well as right. That's the power of negative thinking.