Casting a curious gaze down on planet Earth, extra-terrestrial beings could well be forgiven for assuming that we humans are programmed in every move we make, by a palm-sized, oblong, slab of glass. More perplexing than that, who on earth could convince them otherwise ?
Light and the human is poorly understood by the astronomicalprofession, with many astronomers not understanding which light bulbs they should have in their ownhomes and offices! It is embarrassing that astronomers do not understand the many forms of artificiallighting that they are exposed to every day and how it affects them.
My laboratory is interested in the related challenges of understanding the origin of life on the early earth, and constructing synthetic cellular life in the laboratory. Focusing on artificial life frees us to explore novel chemical systems, but what we learn from these systems helps us to understand possible pathways leading to the origin of life. Our basic design for a synthetic cell involves the encapsulation of a spontaneously replicating nucleic acid, which acts as the genetic material, within a spontaneously replicating membrane vesicle, which provides spatial localization. We are using chemical synthesis to make nucleic acids with modified nucleobases and sugar-phosphate backbones.