The element of chance in basic research is overrated. Chance is a lady who smiles only upon those few who know how to make her smile.

As much as we thirst for approval, we dread condemnation.

To make a great dream come true, you must first have a great dream.

The fairest thing we can experience is the mysterious. It is the fundamental emotion which stands at the cradle of true science. He who knows it not, and can no longer wonder, no longer feel amazement, is as good as dead. We all had this priceless talent when we were young. But as time goes by, many of us lose it. The true scientist never loses the faculty of amazement. It is the essence of his being.

Hans Selye, the pioneer in the understanding of human stress, was often asked the following question: "What is the most stressful condition a person can face?" His unexpected response: "Not having something to BELIEVE in.

Indeed, not all attacks—especially the bitter and ridiculing kind leveled at Darwin—are offered in good faith, but for practical purposes it is good policy to assume that they are.

Adapting the right attitude can convert a negative stress into a positive one.

I doubt that Fleming could have obtained a grant for the discovery of penicillin on that basis [a requirement for highly detailed research plans] because he could not have said, 'I propose to have an accident in a culture so that it will be spoiled by a mould falling on it, and I propose to recognize the possibility of extracting an antibiotic from this mould.

Random search for data on ... off-chance is hardly scientific. A questionnaire on 'Intellectual Immoralities' was circulated by a well-known institution. 'Intellectual Immorality No. 4' read: 'Generalizing beyond one's data'. [Wilder Dwight] Bancroft asked whether it would not be more correct to word question no. 4 'Not generalizing beyond one's data.