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The unsolved problems of the physical world now seem even more formidable than those solved in the twentieth century. Though in application it works splendidly, we do not even understand the physical meaning of quantum mechanics, much less how it might be united with general relativity.We don't know why the dimensionless constants (ratios of masses of elementary particles, ratios of strength of gravitational to electric forces, fine structure constant, etc.) have the values they do, unless we appeal to the implausible anthropic principle, which seems like a regression to Aristotelian teleology.

em Physics, the Human Adventure: From Copernicus to Einstein and Beyond
physics anthropic-principle fine-structure-constant history-of-science constants-of-nature

The power of the deductive network produced in physics has been illustrated in a delightful article by Victor F. Weisskopf. He begins by taking the magnitudes of six physical constants known by measurement: the mass of the proton, the mass and electric charge of the electron, the light velocity, Newton's gravitational constant, and the quantum of action of Planck. He adds three of four fundamental laws (e.g., de Broglie's relations connecting particle momentum and particle energy with the wavelength and frequency, and the Pauli exclusion principle), and shows that one can then derive a host of different, apparently quite unconnected, facts that happen to be known to us by observation separately ....

em The Scientific Imagination: With a New Introduction
physics fine-structure-constant history-of-science constants-of-nature fundamental-laws-of-nature physical-constants victor-weisskopf

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